Microscopic simulation of the chemomechanics of squamous cell tissue

The development of computer technologies makes it possible to implement a mathematical model tissue dynamics, which includes the behavior individual cells. paper describes quasi-two-dimensional tissue, consists cells represented by dynamically changing polygons. two important processes that mimic properties real cells, namely mitotic division and intercalation. An equation motion based on elastic potential energy is written for each vertex polygonal cell. In course evolution, tends take position corresponding minimum energy. allows simple extension case feedback between biomechanical chemical medium introduction several competing types. results numerical simulation heterogeneous carcinoma solid type are given as an example. prospects this approach discussed.